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In this work we describe a system for the monitoring and management of patients with neurodegenerative diseases, focusing on Parkinson's Disease and Amyotrophic Lateral Sclerosis. The system exploits a single wearable sensors' setting to detect and quantify all patient symptoms. An easy to use touchscreen interface allows patients and caregivers to provide additional useful information and assist patients to perform standard predefined tests which otherwise are performed in the clinician's office. The system exploits patient information to suggest appropriate treatment changes based on accumulated medical knowledge. In this paper the architecture of the system, as well as, its innovative features are presented.