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Budding yeast cell cycle modeled by context-sensitive probabilistic Boolean network

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3 Author(s)
Hashimoto, R.F. ; Inst. of Math. & Stat., Univ. of Sao Paulo, Sao Paulo, Brazil ; Stagni, H. ; Higa, C.H.A.

The yeast (Saccharomyces cerevisiae) cell cycle has been studied for years, providing us a good knowledge about this cellular process. However, behind this process, there are still complex interactions between genes and proteins that are not fully understood. In this paper, we present a yeast cell cycle modeled by a context-sensitive probabilistic Boolean network (cPBN). The importance of understanding the cell cycle process under this model is that this knowledge may be useful for inferring other gene regulatory networks (cPBNs) from biological data. Furthermore, this work shows an application of the cPBN model for a real biological system.

Published in:

Genomic Signal Processing and Statistics, 2009. GENSIPS 2009. IEEE International Workshop on

Date of Conference:

17-21 May 2009