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Zhou Wang proposed the Structural Similarity theory (MSSIM), Guan-Hao Chen proposed a marginal texture distorts theory on it. Jian-Xin Pang proposed a method of image quality assessment based on the energy of structural distortion (ESD). Because the theory isn't applied directly on the video field and it don't think over HVS. So we propose a method of video quality assessment based on the sensitive region. First of all, we get the energy of structural distortion (ESD)based on the block. Then, we get the weighted factor according to the structure information and the movement information. Finally, we get the final results according to the HVS. From the last results, we know that the weighting method base on the ESD (WESD) is better than the PSNR, MSSIM and ESSIM on the compression loss, smooth loss and noise loss.