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A lot of masonry buildings have being collapsed during Si Chuan Earthquake (SCE) in western China May 12, at the same time others have being injured on several levers. Now how to evaluate reliability and fragility of the masonry buildings and search reasonable design practice of seismic strengthening of these buildings is urgent mission. One goal of fragility analysis is set up relation between vulnerability and seismic intensity. A stochastic response spectrum of accelerations has being considered as input seismic excitation, fragility curve is also being drawn in relevance with brittle of masonry material property. In the end structural weak position also be pointed as valuable consultation for diagnose these buildings.