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This paper designs one mobile physiological information monitor system based on the ZigBee protocol. The hardware structure is presented. The network communication characteristic of this system was analyzed. The paper points out the disadvantage of the connection method in the ZigBee protocol. One improved connection method is proposed. Through carries on the comparison and the simulation to the routing mechanism of the ZigBee protocol, we choose the Z-AODV routing mechanism. The experimental and simulation results show that the communicational efficiency and stability have been enhanced.