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This paper provides a comparative study of various spatial domain filters for speckle suppression in ultrasound images. Spatial domain filters are easy to implement on real time systems because they work faster than other methods like multi-resolution or wavelets based filters. Different filters have been evaluated experimentally on synthetic and real ultrasound images. Their performance is noted quantitatively using some quality metrics like signal-to-noise ratio (SNR), correlation coefficient (COC), image quality index (QI), structure similarity index (SSI) and edge preserving index (EPI).