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A concept has been developed for a next-generation integrated countermeasure architecture to detect improvised explosive devices hidden on people or left behind in unstructured crowds. The work is part of the Standoff Technology Integration and Demonstration Program of the U.S. Department of Homeland Security's (DHS's) Science and Technology Directorate. The architecture uses a layered-defense approach that automates screening operations, prioritizes threats, and mobilizes resources accordingly. A system tracks people in motion, integrating and automating sensor control and scan acquisition to optimize threat-identification accuracy and allocation of screening resources. A threat-based decision module prioritizes screening targets based on user-defined rules. Operators manage system-wide risk and mobilize field teams for interdiction. DHS is working with industry on technology development and testing to achieve the required level of system integration and economics in crowd conditions.