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Based on a general finite element software named ANSYS/LS-DYAN, using the function of conversion between implicit and explicit, and adopting a research method in which static analysis and dynamic analysis are combined, a research of dynamic response about underground chamber with blasting shock wave in deep environment is carried out by using numerical simulation technology. In the simulation, implicit analysis is used to calculate the gravity function and the deformation of the surrounding rock. By using nodes displacements as an initial condition, explicit dynamic analysis is carried out to simulate the damage effects of blasting load on the adjacent chamber. Compared with measured data, it can be found that there is a basically similar about the waveform between seismic wave in simulation and test, and the attenuation law of peak particle velocity is the same between them. Therefore, combining static analysis with dynamic analysis, numerical simulation technology can grasp the dynamic response of deep underground structures to the blasting vibration further more.