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Fluorine microimaging and quantification using nuclear reaction analysis: A tool for validating tissue distribution of positron emission tomography tracers

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7 Author(s)
Deves, G. ; Chimie Nucléaire Analytique et Bioenvironnementale, UMR 5084, CNRS/Université de Bordeaux, BP 120, 33175 Gradignan Cedex, France ; Roudeau, S. ; Carmona, A. ; Lavielle, S.
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An application of ion beam microprobe analysis has been developed for the quantitative imaging of fluorine compounds in biological samples on a micrometer scale. The difficulty of imaging fluorine at trace level concentration in biological tissues has been addressed by using a combination of nuclear reaction analysis and proton resonant backscattering spectrometry. With this method, the limit of detection of fluorine in thin biological samples can be as low as 3 μg/g. Quantitative imaging of fluorodeoxyglucose distribution, the most widely used tracer for detection of solid tumors by positron emission tomography, is shown as an example of this application.

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Applied Physics Letters  (Volume:95 ,  Issue: 2 )