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This paper describes how to design a suitable micro processor for wireless endoscope. Before designer tune datapath for a specific application, the functions of processor should be analyzed first, and then ESL design tools should be used to make the exploration of design space easy. Additional to customizing processor's architecture and instruction-set, several low-power technologies to improve the performance of such a processor have been introduction. At last, a few real results coming from Tensilica Xtensa and its toolkits show the advantages of ESL design tool for algorithm analysis and customization of processor's architecture and instruction-set.