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One-dimensional DYRESM-CAEDYM model was used to study the effect of water transfer project on water quality of Chaohu Lake, which is situated in central Anhui Province, the lower reaches of Yangtze River. The simulated results of temperature, TN, TP showed good agreement with observed data in 2005. There was also good agreement between monitored data and simulated concentrations of chlorophyll-a although the peaks deviated from observations. Simulations of the water transfer project showed that the concentration of TN decreased 16% and the concentration of TP decreased 19% compared with the case of no water transfer. The peaks of the chlorophyll-a decreased almost 10 ug/L.