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Fatigue testing for twelve SG tubular fabrics with various textile parameters was performed under pulsatile pressure by a new fatigue tester designed and built by our own. Two time points as of 0, and 1.368 times 106 cycles were selected. The percentage change of tubular diameter, fabric count, porosity, and water permeability before and after the fatigue testing were used to characterize the fatigue performance. The mathematical model of quantification theory I was used to analyze the influence of various textile parameters on the fatigue performance of SG textile scaffold. It was found that the predicting results by quantification theory I for the fatigue resistance were relatively accurate and the contribution ratio of each textile parameter to the fatigue performance was also obtained. Different textile parameter has different contribution ratio if different parameters were used to characterize the fatigue performance. Woven construction, yarn size and yarn type had interactive influence on the fatigue performance. This can provide theoretical foundation for making better fatigue resistant SG tubular fabrics.