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We used streptavidin-coated magnetic particles (Dynabeads® M-280) for an immunochromatographic test, instead of colloidal gold particles, which was widely used in a conventional technique. The concentration of magnetic particles in a membrane was quantitatively analyzed by using a giant magnetoresistance (GMR) sensor with a sensitivity of 0.17%/Oe. As a specific zone with a localized concentration of the magnetic particles passed through a GMR sensor, it was observed that the magnitude of sensing signals is proportional to the density of magnetic particles. Therefore, this result suggests that a GMR sensor, which was studied in this paper, can be used for the quantitative detection with a high sensitivity of specific analytes in the immunochromatographic assays, when the analytes were coated on magnetic particles.
Published in:
Journal of Applied Physics
(Volume:105
,
Issue:
7
)
Date of Publication: Apr 2009
- Page(s):
- 07E713 - 07E713-3
- ISSN :
- 0021-8979
- Digital Object Identifier :
- 10.1063/1.3075868
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 24 June 2009
- Issue Date :
- Apr 2009
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