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Application of radical chain reactions to drug release controlling of liposomal carriers under high magnetic fields

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5 Author(s)
Nakagawa, Hidenori ; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan ; Ueno, S. ; Shiina, T. ; Kotani, Makoto
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The use of paramagnetic liposomes modified with radical initiators is a new approach for applications to drug delivery systems. In order to evaluate the potentials of these liposomes, we investigated the effect of 2,2-azobis(2,4-dimethylvaleronitrile) as a radical initiator on the fluidity and permeability of model membranes, using NMR spectroscopy. The results are discussed in terms of the number of unsaturated double bonds in phospholipids of liposomal membranes.

Published in:

Journal of Applied Physics  (Volume:105 ,  Issue: 7 )

Date of Publication:

Apr 2009

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