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A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast

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7 Author(s)
Yuan, Baohong ; Departments of Biomedical Engineering and Radiology, Laboratory for Functional Optical Imaging, Columbia University, New York 10027, USA ; Burgess, Sean A. ; Iranmahboob, Amir ; Bouchard, Matthew B.
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Laminar optical tomography (LOT) is a new three-dimensional in vivo functional optical imaging technique. Adopting a microscopy-based setup and diffuse optical tomography (DOT) imaging principles, LOT can perform both absorption- and fluorescence-contrast imaging with higher resolution (100–200 μm) than DOT and deeper penetration (2–3 mm) than laser scanning microscopy. These features, as well as a large field of view and acquisition speeds up to 100 frames per second, make LOT suitable for depth-resolved imaging of stratified tissues such as retina, skin, endothelial tissues and the cortex of the brain. In this paper, we provide a detailed description of a new LOT system design capable of imaging both absorption and fluorescence contrast, and present characterization of its performance using phantom studies.

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Review of Scientific Instruments  (Volume:80 ,  Issue: 4 )