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Monitoring and anti-counterfeiting for products are important contents of supply chain management, the enterprises which want to open the markets fully, should offer consumers a real-time information inquiry platforms on commodity, and to allow people have a clear understanding of the whole life cycle of the products they consumed and to give the customers a convenient channel to identify the authenticity of the products, but fewer enterprises can monitor whole cycle of products at present. In order to solve this problem, this paper proposes a product life cycle monitoring information system based on RFID and Internet of things. This system fully integrates the technical advantages of RFID and Internet of things, designs products monitoring function modules and products anti-counterfeiting flow chart, and taking mobile with RFID-enabled for example, demonstrates the process of mobile phone anti-counterfeiting. This system gives effective technical references for enterprises to monitor whole life cycle of products with Internet of things.