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A method is presented to calculate point‐defect‐dislocation interaction for dislocations of any orientation in anisotropic crystals. The interaction energy is obtained by consideration of the stress field from the point defect acting against the displacements defining the dislocation. A computer program for stresses around a symmetric point defect in a cubic anisotropic crystal was prepared and successfully employed to calculate the elastic interaction between a symmetric point defect and a number of real mixed dislocations on known slip planes in fcc, bcc, and NaCl‐type crystals. The calculated interactions for the mixed dislocations, considering the anisotropic nature of the crystal, deviate substantially from those based on isotropy, and the deviation is greatest for mixed dislocations near the screw orientation.