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Electronic Deposition of Sprayed Suspensions of Protein for Electron Microscopy

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2 Author(s)
Stasny, J.T. ; Wyeth Laboratories, Incorporated, Radnor, Pennsylvania 19101 ; Rubin, B.A.

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The deposition of microdroplets from a nebulized aerosol is enhanced by the application of an electric field. Electronic deposition facilitates the electron microscopic sampling of the aerosol by capturing those microdroplets that are electrically charged or whose dimensions are too small and therefore elude the more conventional methods of collection. The subsequent deposition of the microdroplets in the system described is a function of the strength of the electric field and the size of the individual microdroplets, and therefore negates the use of forced‐air impaction of the microdroplets onto the collecting surface. Electronic deposition as applied to the collection of nebulized suspensions of particulate protein renders the resulting microdroplets (0.25 to 2.0 μ diameter size range) and their contents accessible to sampling under conditions suitable for high‐resolution electron microscopy.

Published in:

Journal of Applied Physics  (Volume:40 ,  Issue: 1 )