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In this paper conceptions and architectural considerations of the OSAMI project and their specializations towards the requirements of the e-health domain by the German subproject (OSAMI-D) are described. Along with the expected shift of healthcare service between stationary towards ambulatory care, a standardized way of integrating medical data acquired at home into the IT infrastructure of hospitals and the synchronization with medical workflows have to be implemented. Therefore, the OSAMI-D project will provide open source components that implement the required interfaces. Preliminary results of the requirements analysis and the implementation of first domain-specific services are presented. These services are used to realize two home care scenarios, which support ambulant cardiologic rehabilitation (indoor and outdoor). Special emphasis is placed on standards and formats for the communication and storage of patient data.