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Holographic biology found by Chinese Professor Ying-qing Zhang has turned on a new era from the point of view of cognizing the world and has led to a cognitive transform in cognition field and will has broad developmental and applied space. According to systems science and system cognition idea, holographic idea is theoretically explained, it is considered that holographic biomedicine is just a biomedical application of system idea in essence, so holographic biomedicine has gained a theoretical support and scientific foundation. Cognition is a mark of life, is one of the highest forms appearing in the universe, and the ability to think with abstract and ultimate modes helps human to improve cognition from the perception through sense organs up to absolute rational world level, and to get the feeling that the fountain of the universe exists as Dao which as a conception comes from Lao Zi doctrine that is inherited and developed here. Holographic idea is an ultimately evolved form of system idea, and system idea is a kind of holographic units on restricted cognition level. Life bodies are the most complex open giant systems, it is very necessary to use system idea especially holographic idea to direct the researches and applications in biomedical field and many other fields of life sciences.