Cart (Loading....) | Create Account
Close category search window
 

Response of Local Evanescent Array-Coupled Biosensors to Organic Nanofilms

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
Yan, Rongjin ; Dept. of Electr. & Comput. Eng., Colorado State Univ., Fort Collins, CO, USA ; Mestas, S.P. ; Guangwei Yuan ; Safaisini, R.
more authors

A label-free planar optical waveguide immunosensor that operates on the novel principle of local evanescent field shift is demonstrated in this paper. Increased local refractive index at the waveguide's upper surface due to the formation of an organic adlayer shifts the evanescent field distribution up, and hence, changes the light intensity both above and below the waveguide structure. Beam propagation simulations show increased modulation ratio sensitivity to adlayer thickness with increasing detection distance below the waveguide. The local nature of detection allows sensors to be implemented in array formats on a single waveguide for multiple-analyte sensing. Both near-field scanning optical microscopy and integrated buried detector arrays are employed to study the response to patterned organic nanofilms including immunocomplexes, photoresist, and adsorbed bovine serum albumin (BSA) layers. Buried polysilicon detector arrays integrated with silicon nitride waveguides in a commercial CMOS process exhibit a 15% photocurrent modulation ratio response to an approximately 1-nm-thick adsorbed film of BSA. CMOS compatibility enables a low-cost sensor system on a chip. Temperature dependence measurements show that sensor has a 0.3%/degC change in modulation ratio, which is thousands of times less than traditional resonant biosensors.

Published in:

Selected Topics in Quantum Electronics, IEEE Journal of  (Volume:15 ,  Issue: 5 )

Date of Publication:

Sept.-oct. 2009

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.