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Protein structure prediction in the 3D HP model

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4 Author(s)
Kanj, F. ; Dept. of Comput. Sci. & Math., Lebanese American Univ., Beirut ; Mansour, N. ; Khachfe, H. ; Abu-Khzam, F.

Proteins are initially linear chains of amino acids that fold, under the influence of several chemical and physical factors, into their 3-dimensional structures. Due to the importance of this problem and since laboratory techniques are not always feasible, computational methods for characterizing protein structures have been proposed. In this paper, we present a particle swarm optimization (PSO) based algorithm for predicting protein structures in the 3D HP model. Starting from a small set of potential solutions, our algorithm efficiently explores the search space of candidate solutions and returns 3D protein structures with minimal energy. To test our algorithm, we use two sets of benchmark sequences of different lengths. It is found that the results of the PSO algorithm are better than those of previous algorithms.

Published in:

Computer Systems and Applications, 2009. AICCSA 2009. IEEE/ACS International Conference on

Date of Conference:

10-13 May 2009