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COMDES-II is a component-based framework for distributed control systems featuring open architecture and predictable operation under hard real-time constraints. It has been experimentally validated in a number of case studies, including the Medical Ventilator Case Study discussed in the paper. The latter presents COMDES-II design models used to re-engineer the control system of an existing Medical Ventilator machine, and the resulting software implementation. The accumulated experience has helped reveal areas of possible improvement, and they have been taken into consideration while developing the latest version of the framework - COMDES-III.