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A novel approach based on pulse-coupled neural networks (PCNNs) for image change detection is presented. PCNNs are based on the implementation of the mechanisms underlying the visual cortex of small mammals, and, with respect to more traditional NNs architectures, such as multilayer perceptron, own interesting advantages. In particular, they are unsupervised and context sensitive. This latter property may be particularly useful when very high resolution images are considered as, in this case, an object analysis might be more suitable than a pixel-based one. The qualitative and more quantitative results are reported. The performance of the algorithm has been evaluated on a pair of QuickBird images taken over the test area of Tor Vergata University, Rome.