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The present work reports on a class of materials for the combined action of photodynamic therapy (PDT) and hyperthermia therapy (HPT). These materials are designed to work in a synergic way, leading to an expected enhancement of the tumor damage after minimum doses of heat dissipation and/or light photosensitization. Pheophorbide-a (Pheo) has been studied and used for PDT with total absence of dark toxicity to cell by itself. Studies using biocompatible magnetic fluids (MFs) also indicate absence of toxicity without the application of ac magnetic field. The spectroscopic and photophysical properties of the Pheo/MF were investigated to evaluate their photodynamic and HPT characteristics. The results clearly indicate that Pheo presents similar spectroscopic properties associated or not with the MF sample, working efficiently as a photodynamic drug in both conditions.