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Detection of magnetically enhanced cancer tumors using SQUID magnetometry: A feasibility study

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8 Author(s)
Kenning, G.G. ; Department of Physics, Indiana, University of Pennsylvania, Indiana, Pennsylvania 15701 ; Rodriguez, R. ; Zotev, V.S. ; Moslemi, A.
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Nanoparticles bound to various biological molecules and pharmacological agents can be administered systemically, to humans without apparent toxicity. This opens an era in the targeting of specific tissues and disease processes for noninvasive imaging and treatment. An important class of particles used predominantly for magnetic resonance imaging is based on iron-oxide ferrites. We performed computer simulations using experimentally determined values for concentrations of superparamagnetic particles achievable in specific tissues of the mouse in vivo and concentrations of particles linked to monoclonal antibodies specific to antigens of two human cancer cell lines in vitro. An instrument to target distance of 12 cm, into the body, was selected as relevant to our goal of developing a rapid inexpensive method of scanning the body for occult disease. The simulations demonstrate the potential feasibility of superconducting quantum interference device magnetometry to detect induced magnetic fields in focal concentrations of superparamagnetic particles targeted, in vivo, to sites of disease.

Published in:

Review of Scientific Instruments  (Volume:76 ,  Issue: 1 )

Date of Publication:

Jan 2005

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