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This instrument, working in conjunction with standard clinical endoscopes, detects the fluorescence of hematoporphyrin derivative accumulated in tumors. At the same time, the operator receives a conventional image of the target and a signal indicating the intensity of fluorescence. Owing to the simultaneous measurement of fluorescence and backscattered excitation light as a reference, the dependence of this signal on the target vascularization, the target‐endoscope distance, and the viewing angle is strongly reduced over a wide range of these parameters.