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The Tandem‐Mirror Experiment‐Upgrade (TMX‐U) has a large and complex system of Bayard–Alpert, magnetron, and Penning gauges, in addition to mass spectrometers (RGA), all of which measure neutral pressures in the many internal regions of TMX‐U. These pressure measurements are used as part of the confinement physics data base as well as for management of the TMX‐U vacuum system. Dynamic pressures are modeled by a coupled‐volumes simulation code, which includes wall reflux, getter pumping, and plasma pumping.