Notification:
We are currently experiencing intermittent issues impacting performance. We apologize for the inconvenience.
By Topic

Sustained-release silk biomaterials for drug delivery and tissue engineering scaffolds

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

6 Author(s)
Pritchard, E.M. ; Dept. of Biomed. Eng., Tufts Univ., Medford, MA ; Wilz, A. ; Tianfu Li ; Jing-Quan Lan
more authors

Various silk based drug delivery systems were designed to exploit silk's novel material properties in order to attain slow, sustained, controlled release. Using the small molecule model drug adenosine, release profiles from various silk delivery systems were characterized in vitro. The therapeutic potential of the implants was validated in a dose response study in the rat model of kindling epileptogenesis. Adenosine releasing silk implants engineered to release varied target release doses were implanted in rat brains and dose-dependent delays in epileptogenesis were observed over 14 days. We conclude that silk-based adenosine delivery systems represent a safe and efficient strategy to suppress seizures, and that these degradable, implantable biomaterials could potentially be applied to a range of therapeutics.

Published in:

Bioengineering Conference, 2009 IEEE 35th Annual Northeast

Date of Conference:

3-5 April 2009