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Microfabrication of shaped mm-scale tissues to study vascular development

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6 Author(s)
Rivron, N.C. ; Dept. of Tissue Regeneration, Univ. of Twente, Enschede ; Rouwkema, J. ; LeGac, S. ; Truckenmuller, R.
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Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.

Published in:

Bioengineering Conference, 2009 IEEE 35th Annual Northeast

Date of Conference:

3-5 April 2009