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Assessment of baroreflex control of heart rate during general anesthesia using a point process method

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6 Author(s)
Zhe Chen ; Neurosci. Stat. Res. Lab., Harvard Med. Sch., Boston, MA ; Purdon, P.L. ; Pierce, E.T. ; Harrell, G.
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Evaluation of baroreflex control of heart rate (HR) has important implications in clinical practice of anesthesia and postoperative care. In this paper, we present a point process method to assess the dynamic baroreflex gain using a closed-loop model of the cardiovascular system. Specifically, the inverse Gaussian probability distribution is used to model the heartbeat interval, whereas the instantaneous mean is identified by a linear or bilinear bivariate regression on the previous R-R intervals and blood pressure (BP) measures. The instantaneous baroreflex gain is estimated in the feedback loop with a point process filter, while the RRrarrBP feedforward frequency response is estimated by a Kalman filter. In addition, the instantaneous cross-spectrum and cross-bispectrum (as well as their ratio) can also be estimated. All statistical indices provide a valuable quantitative assessment of the interaction between heartbeat dynamics and hemodynamics during general anesthesia.

Published in:

Acoustics, Speech and Signal Processing, 2009. ICASSP 2009. IEEE International Conference on

Date of Conference:

19-24 April 2009

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