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In this paper, the concept of data mining was summarized, and its significance that contributes to commerce was illustrated as well. Based on the characteristic, an important genetic algorithm which is widely used in data mining technology was proposed, whose principle and status were also expatiated. On the other hand, a best employee group of data mining algorithm based on genetic algorithm combining information management system for enterprise employees was proposed, the processes and steps which may solve problem used genetic algorithm as a example. Furthermore, the problems and challenges that data mining technology has to be faced with were discussed.