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Non-invasive in-vivo temperature mapping of ultrasound heating using fluorine-based magnetic resonance imaging agents

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4 Author(s)
Webb, A.G. ; Magnetic Resonance Eng. Lab., Illinois Univ., Urbana, IL, USA ; Smith, N.B. ; Ellis, D.S. ; O'Brien, W.D.

The aim of this study was to investigate the feasibility of using fluorine based magnetic resonance to measure accurately hepatic heating from a focused ultrasound transducer in rats. This new method uses the temperature dependence of the difference in fluorine chemical shifts within a single molecule to provide internal compensation for complicating physiological effects. Female Sprague-Dawley rats were exposed to 5 minutes of CW irradiation at 1.37 MHz from a focused transducer. Theoretical calculations based on the monopole source solution to the bio-heat transfer equation gave a volume-averaged temperature rise of 2.1°C. Preliminary experiments using protein encapsulated perfluorooctylbromide targeted to the liver gave an empirical rise of 2.0±0.4°C

Published in:

Ultrasonics Symposium, 1995. Proceedings., 1995 IEEE  (Volume:2 )

Date of Conference:

7-10 Nov 1995

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