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Detection of magnetically labeled DNA using pseudomorphic AlGaAs/InGaAs/GaAs heterostructure micro-Hall biosensors

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7 Author(s)
Togawa, Kiyoshi ; Department of Electrical and Electronic Engineering, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8552, Japan ; Sanbonsugi, Hideaki ; Sandhu, Adarsh ; Abe, Masanori
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Hall-effect biosensors with a magnetic-field sensitivity of 23 nT/(Hz)1/2 (30×30 μm2, at a drive current of 400 μA) were fabricated using pseudomorphic AlGaAs/InGaAs/GaAs heterostructures for detection of DNA labeled with magnetic beads. Magnetic beads with diameters of 120 nm were selectively immobilized onto the surfaces of the Hall biosensors using highly specific hybridization of complementary oligonucleotides and were subsequently detected by measurement of the ac magnetic susceptibility of the beads.

Published in:

Journal of Applied Physics  (Volume:99 ,  Issue: 8 )