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Magnetic carriers of iron nanoparticles coated with a functional polymer for high throughput bioscreening

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8 Author(s)
Maeda, M. ; Physical Electronics, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan ; Kuroda, C.S. ; Shimura, T. ; Tada, M.
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We synthesized iron nanoparticles, 15–20 nm in size, having saturation magnetization, Ms, of 170 emu/g. They were embedded in copolymer beads of styrene (St) and glycidyl methacrylate (GMA), which were coated with poly-GMA by seed polymerization. The resultant Fe/St-GMA/GMA beads had diameters of 100–200 nm and Ms of 60 emu/g. By coating with poly-GMA, the zeta potential of the beads changed from -93.7 to -54.8 mV, as measured by an electrophoresis method. This facilitated (as revealed by gel electrophoresis method) nonspecific protein adsorption suppression, a requisite for nanoparticles to be applied to carriers for bioscreening.

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Journal of Applied Physics  (Volume:99 ,  Issue: 8 )