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Micromagnetic simulation for detection of a single magnetic microbead or nanobead by spin-valve sensors

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4 Author(s)
Liu, Yaowen ; Department of Physics, Tongji University, Shanghai 200092, China ; Jin, Wei ; Yang, Yaping ; Wang, Zhiguo

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Micromagnetic simulation for detecting magnetic beads is performed by using a high-sensitivity spin-valve sensor as the detector. The magnetic beads polarized by a dc magnetic field contribute to a nonuniform dipole field, which can affect the magnetization state of spin-valve sensor, leading to a detectable resistance change. Simulations show that 2 μm diam microbeads can be detected with ∼98 μV voltage change per bead, which is consistent with the experimental results (∼118 μV per bead), indicating that single molecule detection with a micron-sized bead marker is possible. Detection of a single 250 nm nanobead shows a sensitivity of ∼34 μV, which is close to the present experimental noise level. This suggests that the detection of a single nanosized marker requires enhanced electronic signal by either reducing sensor dimensions or using high-moment ferromagnetic particles as labels.

Published in:

Journal of Applied Physics  (Volume:99 ,  Issue: 8 )