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Detection of DNA labeled with magnetic nanoparticles using MgO-based magnetic tunnel junction sensors

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7 Author(s)
Shen, Weifeng ; Physics Department, Brown University, Providence, Rhode Island 02912, USA ; Schrag, Benaiah D. ; Carter, Matthew J. ; Xie, Jin
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We have demonstrated the detection of 2.5 μM target DNA labeled with 16 nm Fe3O4 nanoparticles (NPs) and 50 nm commercial MACS™ NPs using arrays of magnetic tunnel junction sensors with (001)-oriented MgO barrier layers. Signal-to-noise ratios of 25 and 12 were obtained with Fe3O4 and MACS™ NPs, respectively. These data show conclusively that MgO-based MTJ sensor arrays are very promising candidates for future applications involving the accurate detection and identification of biomolecules tagged with magnetic nanoparticles.

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Journal of Applied Physics  (Volume:103 ,  Issue: 7 )