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In this paper, we propose a novel space-time minimum mean square error (MMSE) decision feedback (DF) detection scheme for direct-sequence code-division multiple access (DS-CDMA) systems with multiple receive antennas, which employs multiple-parallel-feedback (MPF) branches for interference cancellation. The proposed space-time receiver is then further combined with cascaded DF stages to mitigate the deleterious effects of error propagation for uncoded schemes. To adjust the parameters of the receiver, we also present modified adaptive stochastic gradient (SG) and recursive least squares (RLS) algorithms that automatically switch to the best-available interference cancellation feedback branch and jointly estimate the feedforward and feedback filters. The performance of the system with beamforming and diversity configurations is also considered. Simulation results for an uplink scenario with uncoded systems show that the proposed space-time MPF-DF detector outperforms existing schemes such as linear, parallel DF (P-DF), and successive DF (S-DF) receivers in terms of bit error rate (BER) and achieves a substantial capacity increase in terms of the number of users, compared with the existing schemes. We also derive the expressions for MMSE achieved by the analyzed DF structures, including the novel scheme, with imperfect and perfect feedback and expressions of signal-to-interference-plus-noise ratio (SINR) for the beamforming and diversity configurations with linear receivers.