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A 0.18- \mu m CMOS Array Sensor for Integrated Time-Resolved Fluorescence Detection

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5 Author(s)
Huang, T.-c.D. ; Dept. of Electr. Eng., Columbia Univ., New York, NY ; Sorgenfrei, S. ; Gong, P. ; Levicky, R.
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This paper describes the design of an active, integrated CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64-by-64 array is sensitive to photon densities as low as 8.8 times 106 photons/cm2 with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.

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Solid-State Circuits, IEEE Journal of  (Volume:44 ,  Issue: 5 )