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A Phototransistor-Based High-Sensitivity Biosensing System Using 650-nm Light

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4 Author(s)
Yu-Wei Chang ; Dept. of Electron. Eng., Nat. Chiao Tung Univ., Hsinchu ; Yu-Ting Tai ; Yang-Tung Huang ; Yuh-Shyong Yang

A miniature optical biosensing system based on a PMOS phototransistor and absorption photometry is proposed. The phototransistor was manufactured in a standard 0.35-mum CMOS process, and it exhibited a responsivity higher than 1000 A/W for 650-nm light. For biochemical applications, the TMB/H2O2/HRP method was adopted as a useful basis in our system. A sample volume of only 10 mul was required to be dropped on the slide above the phototransistor. Experimental results demonstrated that a high sensitivity of 2.5 muA/pM was achieved, and the minimum HRP concentration successfully detected was 2.7 pM. This detection limit is three orders of magnitude better than that of a lately reported silicon biosensor, and is even comparable to that of a commercial spectrophotometer.

Published in:

Sensors Journal, IEEE  (Volume:9 ,  Issue: 6 )