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This paper presents a comprehensive study on the effective utilization of large-signal measurement data in the nonlinear computer-aided design (CAD) process. To achieve this goal two distinctive, yet mutually complementary, approaches have been integrated. Measured nonlinear data was, in the first instance, directly integrated into a nonlinear CAD simulator, and in the second instance, utilized for a direct extraction of behavioral model parameters. The formulation of the developed model is based on the polyharmonic distortion approach. The combination of both the direct utilization of nonlinear data and the subsequent model generation into an integrated nonlinear design procedure offers rapid, yet reliable, deployment of the CAD-based design environment for complex large-signal simulations.