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Manipulation of biological cells using a microelectromagnet matrix

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3 Author(s)
Lee, H. ; Department of Physics and Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138 ; Purdon, A.M. ; Westervelt, R.M.

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Noninvasive manipulation of biological cells inside a microfluidic channel was demonstrated using a microelectromagnet matrix. The matrix consists of two layers of straight Au wires, aligned perpendicular to each other, that are covered by insulating layers. By adjusting the current in each independent wire, the microelectromagnet matrix can create versatile magnetic field patterns to control the motion of individual cells in fluid. Single or multiple yeast cells attached to magnetic beads were trapped, continuously moved and rotated, and a viable cell was separated from nonviable cells for cell sorting.

Published in:

Applied Physics Letters  (Volume:85 ,  Issue: 6 )

Date of Publication:

Aug 2004

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