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Increased cell response to zirconia ceramics by surface modification

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7 Author(s)
Zhang, Jingxian ; Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China ; Jiang, Dongliang ; Kotobuki, Noriko ; Maeda, Masahiko
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The authors present a method to enhance the cell response to zirconia materials without sacrificing the mechanical properties. Zirconia specimens prepared by slip casting and pressureless sintering have excellent mechanical properties. After hydrothermal treatment in phosphoric solutions at 150 °C for 2 h, enhanced cell proliferation and high alkaline phosphatase activity were determined. This can be explained by the development of a more biocompatible surface phase (zirconium phosphate), which is believed to have high affinity for proteins. Results showed that it was possible to increase the cell response to zirconia ceramics by the proposed surface modification method.

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Applied Physics Letters  (Volume:89 ,  Issue: 18 )