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Quantitative detection of DNA labeled with magnetic nanoparticles using arrays of MgO-based magnetic tunnel junction sensors

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4 Author(s)
Shen, Weifeng ; Physics Department, Brown University, Providence Rhode Island 02912, USA ; Schrag, Benaiah D. ; Carter, Matthew J. ; Xiao, Gang

Your organization might have access to this article on the publisher's site. To check, click on this link:http://dx.doi.org/+10.1063/1.2963970 

We have demonstrated the detection of 2.5 μM target DNA labeled with 16 nm Fe3O4 nanoparticles (NPs) using arrays of magnetic tunnel junction sensors with (001)-oriented MgO barrier layers. A MTJ sensor bridge was designed to detect the presence of magnetic NPs bonded with target DNA. A raw signal of 72 μV was obtained using complementary target DNA, as compared with a nonspecific bonding signal of 25 μV from noncomplementary control DNA. Our results indicate that the current system’s detection limit for analyte DNA is better than 100 nM.

Published in:

Applied Physics Letters  (Volume:93 ,  Issue: 3 )

Date of Publication:

Jul 2008

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