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Localized electroporation and molecular delivery into single living cells by atomic force microscopy

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3 Author(s)
Nawarathna, D. ; Department of Electrical Engineering and Computer Science, University of California, Irvine, California 92697, USA ; Unal, K. ; Wickramasinghe, H.Kumar

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We present an efficient and fast method for selective and localized electroporation of a single living cell from a population of millions to tens of cells using the modified tip of an atomic force microscope. Electroporation was observed in real time using an inverted microscope. This technique is proposed as a tool for efficient and controlled delivery of biomolecules, proteins, drugs, and genes.

Published in:

Applied Physics Letters  (Volume:93 ,  Issue: 15 )