By Topic

Localized electroporation and molecular delivery into single living cells by atomic force microscopy

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

The purchase and pricing options are temporarily unavailable. Please try again later.
3 Author(s)
Nawarathna, D. ; Department of Electrical Engineering and Computer Science, University of California, Irvine, California 92697, USA ; Unal, K. ; Wickramasinghe, H.Kumar

Your organization might have access to this article on the publisher's site. To check, click on this link:http://dx.doi.org/+10.1063/1.2981568 

We present an efficient and fast method for selective and localized electroporation of a single living cell from a population of millions to tens of cells using the modified tip of an atomic force microscope. Electroporation was observed in real time using an inverted microscope. This technique is proposed as a tool for efficient and controlled delivery of biomolecules, proteins, drugs, and genes.

Published in:

Applied Physics Letters  (Volume:93 ,  Issue: 15 )