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In this letter, individual ZnO tetrapod was designed as a multiterminal sensor. The gas-sensing properties of water and oxygen of the device have been investigated. We found that if water was preadsorbed on the device, the sensitivity of oxygen can be effectively enhanced; meanwhile, the response time can also be remarkably shortened. The mechanism of these phenomena, we propose, is the adsorption competition of the two kinds of molecules. Our results show that the preadsorption of appropriate gas can enhance the performance of the sensors, which is helpful for sensor designing.