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Silicon-based nanochannel glucose sensor

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5 Author(s)
Wang, Xihua ; Department of Physics, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA ; Chen, Yu ; Gibney, Katherine A. ; Erramilli, S.
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Silicon nanochannel biological field effect transistors have been developed for glucose detection. The device is nanofabricated from a silicon-on-insulator wafer with a top-down approach and surface functionalized with glucose oxidase. The differential conductance of silicon nanowires, tuned with source-drain bias voltage, is demonstrated to be sensitive to the biocatalyzed oxidation of glucose. The glucose biosensor response is linear in the 0.5–8 mM concentration range with 3–5 min response time. This silicon nanochannel-based glucose biosensor technology offers the possibility of high density, high quality glucose biosensor integration with silicon-based circuitry.

Published in:

Applied Physics Letters  (Volume:92 ,  Issue: 1 )