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Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors

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10 Author(s)
Gui, Ee-Ling ; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave., Singapore 639798, Singapore ; Li, Lain-Jong ; Lee, P.S. ; Lohani, A.
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The authors study deoxyribonucleic acid (DNA) sensing characteristics of carbon nanotube network field-effect transistors (CNNFETs) by monitoring their electrical responses upon immobilization with a DNA probe, hybridization with DNA analytes, and intercalation with a N,N-bis(3-propylimidazole)-1,4,5,8-naphthalene diimide modified with Os(2,2-bipyridine)2Cl+ pendants. The CNNFETs immobilized by single-stranded DNA molecules demonstrate the selective sensing of its complementary and single-base mismatched DNA (difference of ∼16% in reduction of normalized drain current Id). Subsequent intercalation demonstrates a further sensitivity enhancement (difference of ∼13% in Id reduction) due to specific binding between hybridized DNA and intercalators, corroborated by the x-ray photoelectron spectroscopy study.

Published in:

Applied Physics Letters  (Volume:89 ,  Issue: 23 )

Date of Publication:

Dec 2006

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