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This letter reports the measurement of single living cells’ refractive index (RI) using an on-chip fiber-based Fabry-Pérot cavity by a differential method. In experiment a single cell is captured into the cavity, then the spectral shift in response to the buffer change and the cell presence/absence can be used to determine the cell’s RI and size. Experiment on kidney cancer cells measures an effective RI of 1.399 at 0.1% accuracy. Compared with other approaches, the differential method eliminates uncertain factors and thus ensures high accuracy. The microchip facilitates automatic detection and makes it promising for label-free drug screening.
Published in:
Applied Physics Letters
(Volume:89
,
Issue:
20
)
Date of Publication: Nov 2006
- Page(s):
- 203901 - 203901-3
- ISSN :
- 0003-6951
- Digital Object Identifier :
- 10.1063/1.2387965
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 18 June 2009
- Issue Date :
- Nov 2006
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