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Detection of nano-confined DNA using surface-plasmon enhanced fluorescence

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3 Author(s)
Cloutier, Sylvain G. ; Division of Engineering and Department of Physics, Brown University, Providence, Rhode Island 02912 ; Lazareck, Adam D. ; Xu, Jimmy

Your organization might have access to this article on the publisher's site. To check, click on this link:http://dx.doi.org/+10.1063/1.2161813 

Surface-plasmon resonance (SPR)-induced enhanced fluorescence was used to detect the presence of fluorescent TOTO-1 bis-intercalated lambda-DNA complexes introduced into a periodic nanopore array. As we show, the proposed technique allows a high detection sensitivity by providing a strong fluorescence-signal efficiency from nano-confined fluorescent complexes. This novel platform could be used for sensing applications, or to detect and investigate the unique behaviors of nano-confined molecular systems.

Published in:

Applied Physics Letters  (Volume:88 ,  Issue: 1 )

Date of Publication:

Jan 2006

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